Altered functions of γδ T cells in acute HIV infection.

<p>Cytotoxicity (%) was assessed at different effector (E, γδ T cells) to target (T, Daudi cells) ratios (0.1∶1, 0.5µ1 and 1∶1) at baseline (<b>A</b>). Subsequently, longitudinal follow-up analysis of cytotoxicity was conducted at different time-points [baseline, month 6 (M6), month 12 (M12) and month 18 (M18)] (<b>B</b>). Frequencies of IFN-γ- and IL-17-producing γδ T cells were analyzed in healthy controls (HC) and acutely HIV-infected subjects at baseline (<b>C, E</b>). The patients were then subdivided based on the administration of antiretroviral therapy (ART) and CD4 levels (< or >than 350/µL). The frequencies were re-analyzed and compared with HC (<b>D, F</b>). *: <i>P</i><0.05, **: <i>P</i><0.01.