BM-derived hepatocytes emerged from fusion between donor BM-derived myelomonocytic cells and host hepatocytes.

<p>(A) Donor-derived hepatocyte measurements from <i>EGFP-BMT</i> (top), <i>C3H-BMT</i> (middle), and <i>rat-BMT</i> mice (bottom). Gated donor-derived hepatocytes mostly expressed CD45, and the same hepatocytes were partially positive for recipient MHC class I antigen. EGFP⁺, H-2K^k+, or RT1A⁺ hepatocytes represent donor antigen, while H-2D^b+ represent recipient MHC antigen. (B) Immunophenotyping of bone marrow-derived hepatocytes in <i>EGFP-BMT</i> mice. Recipient derived hepatocytes (R2) were negative for CD45, F4/80, Gr-1, CD11b, CD11c staining, while donor derived hepatocytes (R3) were mostly positive for CD45, F4/80, Gr-1, and CD11b, but negative for CD11c. (Numbers indicate the percentage of each population).