Expression of total SMN protein in undifferentiated as well as MN-differentiated control and SMA cells.

<p>Representative immunoblots of both differentiated and undifferentiated mESCs revealed a significantly reduced protein expression of SMN in A2 SMA cell lines compared to Hb9 control cells. SMN levels were normalized to Gapdh. C = control, S = SMA. Asterisks indicate significant differences compared to controls (*p<0.05, Student's <i>t</i> test).