Effect of Betulinic acid, Thymoquinone and Gemcitabine alone and (in combination) on growth of human pancreatic tumor cell lines.
- Archana Pandita (627056)
- Bhupender Kumar (430944)
- Siddharth Manvati (391250)
- Samantha Vaishnavi (627057)
- Shashank K. Singh (627058)
- Rameshwar N. K. Bamezai (123255)
Publication date
September 2014
DOIAbstract
<p><i>(A) MIA PaCa-2 and (B) PANC-1 cells were exposed to graded concentrations of Betulinic acid, Thymoquinone or Gemcitabine either alone or in combination at a fixed dose ratio of Betulinic acid vs. Gemcitabine and Thymoquinone vs. Gemcitabine for 48 hrs.(Gemcitabine</i><i>having exposure for 24 hrs only in case of combination), Gemcitabine (squares),</i><i>Betulinic acid and Thymoquinone</i><i>(circle) Gemcitabine+ betulinic acid and Gemcitabine +Thymoquinone (triangle).(Mono therapy (BA, GCB, TQ) Versus Combinations(CI<sub>(GCB:BA)</sub>, CI<sub>(GCB:TQ)</sub>)(**, significant difference at p value <0.01, n = 3).</i></p
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