Summary of included studies.

a<p>The visual score criteria consider 1+ or more staining as positive.</p>b<p>The visual score criteria consider 2+ or 3+ staining as positive.</p>c<p>Q score was calculated by multiplying the percentage (P, 0–100%) of positive cells by the intensity (I, 0–3) of staining (Q = P*I; maximum = 300) <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0105940#pone.0105940-Kozu1" target="_blank">[30]</a>.</p><p>Abbreviations: IHC, immunohistochemistry; TMA, tissue microarray; AUC, the best area under the ROC curves; TP, true positive; FP, false positive; FN, false negative; TN, true negative; PCR-RFLP, Polymerase chain reaction-restriction fragment length polymorphism; HRMA, high resolution melting analysis.</p><p>Summary of included studies.