<p>(A) Murine MD-2 mutants mE122K and mE122K L125K gain the ability to activate the human TLR4 with hexaacylated endotoxin. (B) Murine MD-2 mutants mE122K and mE122K L125K in combination with murine TLR4 exhibit reduced activation by tetraacylated lipid IVa.</p
<p>DCs derived from C57BL6 (B6 WT), TLR2<sup>−/−</sup>, C3H/HeOuJ (C3H WT), C3H/HeJ (TLR4 mutant) (A...
<p>Responsiveness to different types of endotoxins by combinations of MD-2 and TLR4.</p
TLR4 polymorphisms such as Asp299Gly and Thr399Ile related to Gram-negative sepsis have been reporte...
Lipopolysaccharide (LPS) activates the innate immune response through the Toll-like receptor 4 (TLR4...
The Toll-like receptor 4/MD-2 receptor complex recognizes endotoxin, a Gram-negative bacterial cell ...
<div><p>The Toll-like receptor 4/MD-2 receptor complex recognizes endotoxin, a Gram-negative bacteri...
MD-2 is an accessory protein of the Toll-like receptor (TLR)-4, necessary for assembling a receptor ...
<p>(A) The surface representation of human MD-2 (2E56, <a href="http://www.plosone.org/article/info:...
The Toll-like receptor 4/MD-2 receptor complex recognizes endotoxin, a Gram-negative bacterial cell ...
The detection of Gram-negative LPS depends upon the proper function of the TLR4-MD-2 receptor comple...
Synthetic forms of E. coli monophosphoryl lipid A (sMLA) weakly activate the MyD88 (myeloid differen...
<p>(A) hTLR4 amino acid residues that are essential for activation by LPS are not needed for activat...
Synthetic forms of E. coli monophosphoryl lipid A (sMLA) weakly activate the MyD88 (myeloid differen...
Myeloid differentiation factor 2 (MD-2) is a secreted gp that assembles with TLR4 to form a function...
There is literature evidence gathered throughout the last two decades reflecting unexpected species ...
<p>DCs derived from C57BL6 (B6 WT), TLR2<sup>−/−</sup>, C3H/HeOuJ (C3H WT), C3H/HeJ (TLR4 mutant) (A...
<p>Responsiveness to different types of endotoxins by combinations of MD-2 and TLR4.</p
TLR4 polymorphisms such as Asp299Gly and Thr399Ile related to Gram-negative sepsis have been reporte...
Lipopolysaccharide (LPS) activates the innate immune response through the Toll-like receptor 4 (TLR4...
The Toll-like receptor 4/MD-2 receptor complex recognizes endotoxin, a Gram-negative bacterial cell ...
<div><p>The Toll-like receptor 4/MD-2 receptor complex recognizes endotoxin, a Gram-negative bacteri...
MD-2 is an accessory protein of the Toll-like receptor (TLR)-4, necessary for assembling a receptor ...
<p>(A) The surface representation of human MD-2 (2E56, <a href="http://www.plosone.org/article/info:...
The Toll-like receptor 4/MD-2 receptor complex recognizes endotoxin, a Gram-negative bacterial cell ...
The detection of Gram-negative LPS depends upon the proper function of the TLR4-MD-2 receptor comple...
Synthetic forms of E. coli monophosphoryl lipid A (sMLA) weakly activate the MyD88 (myeloid differen...
<p>(A) hTLR4 amino acid residues that are essential for activation by LPS are not needed for activat...
Synthetic forms of E. coli monophosphoryl lipid A (sMLA) weakly activate the MyD88 (myeloid differen...
Myeloid differentiation factor 2 (MD-2) is a secreted gp that assembles with TLR4 to form a function...
There is literature evidence gathered throughout the last two decades reflecting unexpected species ...
<p>DCs derived from C57BL6 (B6 WT), TLR2<sup>−/−</sup>, C3H/HeOuJ (C3H WT), C3H/HeJ (TLR4 mutant) (A...
<p>Responsiveness to different types of endotoxins by combinations of MD-2 and TLR4.</p
TLR4 polymorphisms such as Asp299Gly and Thr399Ile related to Gram-negative sepsis have been reporte...
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