Comparison of ages at onset of diabetes mellitus and optic atrophy in subjects with and without a mutated WFS1 gene.

Identification of a missense variant in the WFS1 gene that causes a mild form of Wolfram syndrome and is associated with risk for type 2 diabetes in Ashkenazi Jewish individuals

Bansal, Vikas
Boehm, Bernhard O.
Darvasi, Ariel

January 2018

Aims/hypothesis Wolfram syndrome is a rare, autosomal recessive syndrome characterised by juvenile-o...

Mean (±SD) age and gender distribution and clinical variables for control groups and WFS group for MPRAGE scans.

Tamara Hershey (316326)
Heather M. Lugar (316327)
Joshua S. Shimony (152927)
Jerrel Rutlin (316328)
Jonathan M. Koller (316329)
Dana C. Perantie (316330)
Alex R. Paciorkowski (316331)
Sarah A. Eisenstein (316332)
M. Alan Permutt (86951)

February 2013

Abbreviation. HC: healthy controls; T1C: diabetic controls; WFS: Wolfram Syndrome group; SD: stan...

Two Cases of Wolfram Syndrome Who Were Initially Diagnosed With Type 1 Diabetes

Silvestri F.
Tromba V.
Costantino F.
Palaniappan N.
Urano F.

January 2022

Objective: Early diagnosis of syndromic monogenic diabetes allows for proper management and can lead...

Analysis of genotype-phenotype correlations for WFS1 mutations.

Kimie Matsunaga (628349)
Katsuya Tanabe (86942)
Hiroshi Inoue (32292)
Shigeru Okuya (628350)
Yasuharu Ohta (628351)
Masaru Akiyama (338518)
Akihiko Taguchi (363459)
Yukari Kora (628352)
Naoko Okayama (628353)
Yuichiro Yamada (628354)
Yasuhiko Wada (628355)
Shin Amemiya (628356)
Shigetaka Sugihara (628357)
Yuzo Nakao (628358)
Yoshitomo Oka (548202)
Yukio Tanizawa (352650)

September 2014

Ages at onset of both diabetes mellitus (A) and optic atrophy (B) in each patient in the three gr...

Clinical characteristics and family history of each patient screened for WFS1 mutations.

Kimie Matsunaga (628349)
Katsuya Tanabe (86942)
Hiroshi Inoue (32292)
Shigeru Okuya (628350)
Yasuharu Ohta (628351)
Masaru Akiyama (338518)
Akihiko Taguchi (363459)
Yukari Kora (628352)
Naoko Okayama (628353)
Yuichiro Yamada (628354)
Yasuhiko Wada (628355)
Shin Amemiya (628356)
Shigetaka Sugihara (628357)
Yuzo Nakao (628358)
Yoshitomo Oka (548202)
Yukio Tanizawa (352650)

September 2014

*M, male; F, female; DM, diabetes mellitus; OA, optic atrophy; D, deafness; DI, diabetes insipidu...

Analysis of age-dependent gene-expression in human tissues for studying diabetes comorbidities

Pietro Hiram Guzzi
Francesca Cortese
Gaia Chiara Mannino
Elisabetta Pedace
Elena Succurro
Francesco Andreozzi
Pierangelo Veltri

June 2023

Abstract The study of the relationship between type 2 diabetes mellitus (T2DM) disease and other pat...

Genotype-wise association analysis of the investigated WFS1 SNPs and diabetes mellitus using recessive model.

Zsuzsanna Elek (509409)
Nóra Németh (3286569)
Géza Nagy (802329)
Helga Németh (802330)
Anikó Somogyi (362442)
Nóra Hosszufalusi (802331)
Mária Sasvári-Székely (3286572)
Zsolt Rónai (3286566)

October 2015

Genotype-wise association analysis of the investigated WFS1 SNPs and diabetes mellitus usi...

The Common HNF1A Variant I27L is a Modifier of Age at Diabetes Diagnosis in HNF1A-MODY Individuals.

Locke, J. M.
Saint-Martin, C.
Laver, T. W.
Patel, K. A.
Wood, A. R.
Sharp, S. A.
Ellard, Sian
Bellanné-Chantelot, C.
Hattersley, Andrew T.
Harries, L. W.
Weedon, M. N.

June 2018

There is wide variation in the age at diagnosis of diabetes in individuals with Maturity-Onset Diabe...

DNA methylation age calculators reveal association with diabetic neuropathy in type 1 diabetes

Roshandel, Delnaz
Chen, Zhuo
Canty, Angelo J
Bull, Shelley B
Natarajan, Rama
Paterson, Andrew D

December 2020

BackgroundMany CpGs become hyper or hypo-methylated with age. Multiple methods have been developed b...

Susceptibility Modify Age at Diagnosis in Monogenic HNF1A Diabetes

Hana Lango Allen
Stefan Johansson
Sian Ellard
Beverley Shields
Jens K. Hertel
Helge Ræder
Kevin Colclough
Anders Molven
Timothy M. Frayling
Pål R. Njølstad
Andrew T. Hattersley
Michael N. Weedon

August 2016

OBJECTIVE—Mutations in the HNF1A gene are the most common cause of maturity-onset diabetes of the yo...

Juvenile diabetes and visual impairment: Wolfram syndrome

Ellard, Sian
De Franco, Elisa

October 2019

This article is freely available via Open Access. Click on the Publisher URL to access it via the pu...

Mutations Evidence for parent-of-origin effect TOMASZ KLUPA, MD1,2,3

James H. Warram
Anthony Antonellis Bs
Marcus Pezzolesi Bs
Stephen S. Rich

September 2016

OBJECTIVE — To determine the distribution of the age at onset of diabetes (maturity-onset diabetes o...

OBSERVATION OF THE ROLE OF THE GENES IN THE CHILD AND DETERMINATION OF THE CHANCE OF TYPE 1 DIABETES

Dr. Ayesha Sajjad, Dr Sadaf Aslam, Dr Amna Mahmood

November 2020

The type 1 diabetes is a type of diabetes in patient has high sugar and glucose level. It comes in s...

Mean (±SD) age and gender distribution and clinical variables for control groups and WFS group for DTI scans.

Tamara Hershey (316326)
Heather M. Lugar (316327)
Joshua S. Shimony (152927)
Jerrel Rutlin (316328)
Jonathan M. Koller (316329)
Dana C. Perantie (316330)
Alex R. Paciorkowski (316331)
Sarah A. Eisenstein (316332)
M. Alan Permutt (86951)

February 2013

Abbreviation. HC: healthy controls; T1C: diabetic controls; WFS: Wolfram Syndrome group; SD: stan...

[From gene to disease; mutations in the WFS1-gene as the cause of juvenile type I diabetes mellitus with optic atrophy (Wolfram syndrome)]

Pennings, R.J.E.
Dikkeschei, L.D.
Cremers, C.W.R.J.
Ouweland, J.M.W. van den

January 2002

Item does not contain fulltextWolfram syndrome patients are mainly characterised by juvenile onset d...

Identification of a missense variant in the WFS1 gene that causes a mild form of Wolfram syndrome and is associated with risk for type 2 diabetes in Ashkenazi Jewish individuals

Bansal, Vikas
Boehm, Bernhard O.
Darvasi, Ariel

January 2018

Aims/hypothesis Wolfram syndrome is a rare, autosomal recessive syndrome characterised by juvenile-o...

Mean (±SD) age and gender distribution and clinical variables for control groups and WFS group for MPRAGE scans.

Tamara Hershey (316326)
Heather M. Lugar (316327)
Joshua S. Shimony (152927)
Jerrel Rutlin (316328)
Jonathan M. Koller (316329)
Dana C. Perantie (316330)
Alex R. Paciorkowski (316331)
Sarah A. Eisenstein (316332)
M. Alan Permutt (86951)

February 2013

Abbreviation. HC: healthy controls; T1C: diabetic controls; WFS: Wolfram Syndrome group; SD: stan...

Two Cases of Wolfram Syndrome Who Were Initially Diagnosed With Type 1 Diabetes

Silvestri F.
Tromba V.
Costantino F.
Palaniappan N.
Urano F.

January 2022

Objective: Early diagnosis of syndromic monogenic diabetes allows for proper management and can lead...

Analysis of genotype-phenotype correlations for WFS1 mutations.

Kimie Matsunaga (628349)
Katsuya Tanabe (86942)
Hiroshi Inoue (32292)
Shigeru Okuya (628350)
Yasuharu Ohta (628351)
Masaru Akiyama (338518)
Akihiko Taguchi (363459)
Yukari Kora (628352)
Naoko Okayama (628353)
Yuichiro Yamada (628354)
Yasuhiko Wada (628355)
Shin Amemiya (628356)
Shigetaka Sugihara (628357)
Yuzo Nakao (628358)
Yoshitomo Oka (548202)
Yukio Tanizawa (352650)

September 2014

Ages at onset of both diabetes mellitus (A) and optic atrophy (B) in each patient in the three gr...

Clinical characteristics and family history of each patient screened for WFS1 mutations.

Kimie Matsunaga (628349)
Katsuya Tanabe (86942)
Hiroshi Inoue (32292)
Shigeru Okuya (628350)
Yasuharu Ohta (628351)
Masaru Akiyama (338518)
Akihiko Taguchi (363459)
Yukari Kora (628352)
Naoko Okayama (628353)
Yuichiro Yamada (628354)
Yasuhiko Wada (628355)
Shin Amemiya (628356)
Shigetaka Sugihara (628357)
Yuzo Nakao (628358)
Yoshitomo Oka (548202)
Yukio Tanizawa (352650)

September 2014

*M, male; F, female; DM, diabetes mellitus; OA, optic atrophy; D, deafness; DI, diabetes insipidu...

Analysis of age-dependent gene-expression in human tissues for studying diabetes comorbidities

Pietro Hiram Guzzi
Francesca Cortese
Gaia Chiara Mannino
Elisabetta Pedace
Elena Succurro
Francesco Andreozzi
Pierangelo Veltri

June 2023

Abstract The study of the relationship between type 2 diabetes mellitus (T2DM) disease and other pat...

Genotype-wise association analysis of the investigated WFS1 SNPs and diabetes mellitus using recessive model.

Zsuzsanna Elek (509409)
Nóra Németh (3286569)
Géza Nagy (802329)
Helga Németh (802330)
Anikó Somogyi (362442)
Nóra Hosszufalusi (802331)
Mária Sasvári-Székely (3286572)
Zsolt Rónai (3286566)

October 2015

Genotype-wise association analysis of the investigated WFS1 SNPs and diabetes mellitus usi...

The Common HNF1A Variant I27L is a Modifier of Age at Diabetes Diagnosis in HNF1A-MODY Individuals.

Locke, J. M.
Saint-Martin, C.
Laver, T. W.
Patel, K. A.
Wood, A. R.
Sharp, S. A.
Ellard, Sian
Bellanné-Chantelot, C.
Hattersley, Andrew T.
Harries, L. W.
Weedon, M. N.

June 2018

There is wide variation in the age at diagnosis of diabetes in individuals with Maturity-Onset Diabe...

DNA methylation age calculators reveal association with diabetic neuropathy in type 1 diabetes

Roshandel, Delnaz
Chen, Zhuo
Canty, Angelo J
Bull, Shelley B
Natarajan, Rama
Paterson, Andrew D

December 2020

BackgroundMany CpGs become hyper or hypo-methylated with age. Multiple methods have been developed b...

Susceptibility Modify Age at Diagnosis in Monogenic HNF1A Diabetes

Hana Lango Allen
Stefan Johansson
Sian Ellard
Beverley Shields
Jens K. Hertel
Helge Ræder
Kevin Colclough
Anders Molven
Timothy M. Frayling
Pål R. Njølstad
Andrew T. Hattersley
Michael N. Weedon

August 2016

OBJECTIVE—Mutations in the HNF1A gene are the most common cause of maturity-onset diabetes of the yo...

Juvenile diabetes and visual impairment: Wolfram syndrome

Ellard, Sian
De Franco, Elisa

October 2019

This article is freely available via Open Access. Click on the Publisher URL to access it via the pu...

Mutations Evidence for parent-of-origin effect TOMASZ KLUPA, MD1,2,3

James H. Warram
Anthony Antonellis Bs
Marcus Pezzolesi Bs
Stephen S. Rich

September 2016

OBJECTIVE — To determine the distribution of the age at onset of diabetes (maturity-onset diabetes o...

OBSERVATION OF THE ROLE OF THE GENES IN THE CHILD AND DETERMINATION OF THE CHANCE OF TYPE 1 DIABETES

Dr. Ayesha Sajjad, Dr Sadaf Aslam, Dr Amna Mahmood

November 2020

The type 1 diabetes is a type of diabetes in patient has high sugar and glucose level. It comes in s...

Mean (±SD) age and gender distribution and clinical variables for control groups and WFS group for DTI scans.

Tamara Hershey (316326)
Heather M. Lugar (316327)
Joshua S. Shimony (152927)
Jerrel Rutlin (316328)
Jonathan M. Koller (316329)
Dana C. Perantie (316330)
Alex R. Paciorkowski (316331)
Sarah A. Eisenstein (316332)
M. Alan Permutt (86951)

February 2013

Abbreviation. HC: healthy controls; T1C: diabetic controls; WFS: Wolfram Syndrome group; SD: stan...

[From gene to disease; mutations in the WFS1-gene as the cause of juvenile type I diabetes mellitus with optic atrophy (Wolfram syndrome)]

Pennings, R.J.E.
Dikkeschei, L.D.
Cremers, C.W.R.J.
Ouweland, J.M.W. van den

January 2002

Item does not contain fulltextWolfram syndrome patients are mainly characterised by juvenile onset d...

Identification of a missense variant in the WFS1 gene that causes a mild form of Wolfram syndrome and is associated with risk for type 2 diabetes in Ashkenazi Jewish individuals

Bansal, Vikas
Boehm, Bernhard O.
Darvasi, Ariel

January 2018

Aims/hypothesis Wolfram syndrome is a rare, autosomal recessive syndrome characterised by juvenile-o...

Mean (±SD) age and gender distribution and clinical variables for control groups and WFS group for MPRAGE scans.

Tamara Hershey (316326)
Heather M. Lugar (316327)
Joshua S. Shimony (152927)
Jerrel Rutlin (316328)
Jonathan M. Koller (316329)
Dana C. Perantie (316330)
Alex R. Paciorkowski (316331)
Sarah A. Eisenstein (316332)
M. Alan Permutt (86951)

February 2013

Abbreviation. HC: healthy controls; T1C: diabetic controls; WFS: Wolfram Syndrome group; SD: stan...

Two Cases of Wolfram Syndrome Who Were Initially Diagnosed With Type 1 Diabetes

Silvestri F.
Tromba V.
Costantino F.
Palaniappan N.
Urano F.

January 2022

Objective: Early diagnosis of syndromic monogenic diabetes allows for proper management and can lead...

Comparison of ages at onset of diabetes mellitus and optic atrophy in subjects with and without a mutated <i>WFS1</i> gene.

Abstract

Extracted data

Comparison of ages at onset of diabetes mellitus and optic atrophy in subjects with and without a mutated <i>WFS1</i> gene.

Abstract

Extracted data

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