Upon overlaying Cα atoms in second structural region and heme backbone atoms, the conformational comparison: (A) between wild-type cyt <i>c</i> (grey, pdb code 1YIC) and its Y67H variant (green); (B) between the Y67F (<i>magenta</i>, pdb code 1CTY) and Y67H (green) mutants; (C) between Y67H (green) and alkaline form (red, pdb code 1LMS).

<p>Upon overlaying Cα atoms in second structural region and heme backbone atoms, the conformational comparison: (A) between wild-type cyt <i>c</i> (grey, pdb code 1YIC) and its Y67H variant (green); (B) between the Y67F (<i>magenta</i>, pdb code 1CTY) and Y67H (green) mutants; (C) between Y67H (green) and alkaline form (red, pdb code 1LMS).