<p>For how compound A398 induced apoptosis in the leukemic HL-60 cells through the activation of the extrinsic and intrinsic pathways of death and its action on molecular targets, such as caspases, the anti-apoptotic protein Bcl-2 and MAPK proteins (ERK1/2, JNK and p38).</p
The stress-activated c-Jun N-terminal protein kinase (JNK) and p38 mitogen-activated protein (MAP) k...
Many studies have led to the identification of molecules involved in the signaling to cell death and...
The antiapoptotic role of Bcl-2 can be regulated by its phosphorylation in serine and threonine resi...
<p>Cells were treated with A398 (4, 6 and 8 µM) or etoposide (5 µM) for 1 h, 3 h or 6 h and stained ...
<div><p>Despite advances in oncology research, cancer is one of the leading causes of death worldwid...
Despite advances in oncology research, cancer is one of the leading causes of death worldwide. Thus,...
Via inhibition of the PI3K/Akt/mTOR signaling pathway, compound FD268 diminished the survival and pr...
Two novel, modified thymidine nucleosides, 5-phenylselenyl-methyl-2'-deoxyuridine (PhSe-T) and 5-met...
TNF-α transduces signals of survival or death via its two receptors, R1/p55/p60 and RII/p80/p75. The...
Apoptosis is vital in maintaining homeostasis, and its deregulation can have dire pathological conse...
The aim of the present study was to discover the signaling pathways associated with 2-(3...
Anthracyclines have been first line drugs for more than 3 decades in the treatment of acute myelogen...
LL-37 is a human cationic host defense peptide (antimicrobial peptide) belonging to the cathelicidin...
AbstractActivation of several different kinases characterizes the induction of apoptosis. Abelson vi...
<p>The proposed model shows that 316L SS and HNNF SS cause cell apoptosis through extrinsic apoptosi...
The stress-activated c-Jun N-terminal protein kinase (JNK) and p38 mitogen-activated protein (MAP) k...
Many studies have led to the identification of molecules involved in the signaling to cell death and...
The antiapoptotic role of Bcl-2 can be regulated by its phosphorylation in serine and threonine resi...
<p>Cells were treated with A398 (4, 6 and 8 µM) or etoposide (5 µM) for 1 h, 3 h or 6 h and stained ...
<div><p>Despite advances in oncology research, cancer is one of the leading causes of death worldwid...
Despite advances in oncology research, cancer is one of the leading causes of death worldwide. Thus,...
Via inhibition of the PI3K/Akt/mTOR signaling pathway, compound FD268 diminished the survival and pr...
Two novel, modified thymidine nucleosides, 5-phenylselenyl-methyl-2'-deoxyuridine (PhSe-T) and 5-met...
TNF-α transduces signals of survival or death via its two receptors, R1/p55/p60 and RII/p80/p75. The...
Apoptosis is vital in maintaining homeostasis, and its deregulation can have dire pathological conse...
The aim of the present study was to discover the signaling pathways associated with 2-(3...
Anthracyclines have been first line drugs for more than 3 decades in the treatment of acute myelogen...
LL-37 is a human cationic host defense peptide (antimicrobial peptide) belonging to the cathelicidin...
AbstractActivation of several different kinases characterizes the induction of apoptosis. Abelson vi...
<p>The proposed model shows that 316L SS and HNNF SS cause cell apoptosis through extrinsic apoptosi...
The stress-activated c-Jun N-terminal protein kinase (JNK) and p38 mitogen-activated protein (MAP) k...
Many studies have led to the identification of molecules involved in the signaling to cell death and...
The antiapoptotic role of Bcl-2 can be regulated by its phosphorylation in serine and threonine resi...
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