ARQ 197 and GDC-0980 inhibit the growth of tumor xenografts in nude mice and their combination has synergistic inhibition of tumor growth.

<p>Results from tumor xenograft experiments testing the efficacy of ARQ 197 and GDC-0980 alone and/or combination in inhibiting the growth of H2596 cell line tumors in nude mice. Oral gavage treatment with ARQ 197 (200 mg/kg/day) and/or GDC-0980 (5 mg/kg/day) reduced H2596 tumor growth significantly relative to vehicle control (p<0.001). The combined use of ARQ 197/GDC-0980 was much more effective than any single agent alone, in inhibiting the tumor growth (p<0.01). <b>(A)</b> Tumor sizes were recorded every three days till the end of the experiment. <b>(B)</b> Representative images of mice and tumors treated with vehicle control, ARQ 197, GDC-0980 and their combination. <b>(C)</b> Immunohistochemical staining of tumor tissues with total CD31 and p-AKT and quantification. Bar graphs indicate average expression with standard error.