Comparison between recorded and simulated granule cell responses.

<p>(A) Histogram of the recorded granule cell response to 1 pulse stimulation to the SBC tract at 0.3 mA (black line) compared to a histogram with the average spike output of the model (grey line). The 95% confidence bound of the simulation response is shown as a grey area behind the lines. The instantaneous firing frequency (IFF) is shown for comparison with the firing probability and equals the firing probability divided by the bin width. The arrows indicate the time of stimulation both related to the synaptic input to the model (left inset), and superimposed example traces of the simulated response (right inset). (B) Same granule cell and model as in (A) but with a 3 pulse stimulus (3 ms inter-pulse intervals). (C) The response of a different granule cell, and its adapted model, to a 1 pulse stimulus of the SBC tract. Note that the models in (A) and (C) only differ with respect to the resting membrane potential of the granule cells and the latency of the EPSP input (compare left insets). (D) Same as in (C) but with a 3 pulse stimulus (3 ms inter-pulse intervals).