Phosphorylation and expression level of IGF-1R in brain.

<p>Left: representative western blot showing P-IGF-1R and total IGF-1R immunoreactivity in control (C) or HU14 groups. Middle: level of phosphorylation of IGF-1R, expressed as the ratio between P-IGF-1R and IGF-1R, in C and HU14 groups. * and *** p<0.05 and p<0.001 respectively, with respect to C group. Right: expression of IGF-1R, corresponding to the ratio between IGF-1R and α-tubulin). Values are mean ± SEM.