Up-regulation of CT genes in parallel to MET in the Caco-2 SD model.

<p>Relative mRNA expression of CT genes (<i>PAGE2</i>, <i>-2B</i> and <i>SPANXB</i>) (<b>A</b>), epithelial genes (<i>E-cadherin (CDH1)</i>, <i>claudin 4(CLDN4)</i>, <i>CDX2</i>) (<b>B</b>), and mesenchymal genes (<i>fibronectin 1 (FN1), vimentin (VIM)</i>, <i>transgelin (TAGLN)</i>) (<b>C</b>) as determined by quantitative PCR at days 0, 10, 20 and 30 post-confluence. Data represent average of two experiments. Change in expression levels for all genes between days 0 and 30 is statistically significant (P<0.0001, by two way ANOVA with Tukey's post hoc test).