EPPK^−/− mice show no abnormalities regarding their acinar keratin organization and junctional complexes.

<p>(A) Immunofluorescence microscopy for K8 in pancreata from wild-type and EPPK^−/− mice reveal no differences in keratin network structure of acinar cells. (B–E) Immunofluorescence microscopy analysis using antibodies to desmoplakin (B, C) e-cadherin (D, E) and occludin (F, G) shows no differences in intensity and localization of these junctional proteins between wild-type and EPPK^−/− mice in unstressed tissue (B, D, F) and during pancreatitis (C, E, G). Note the disassembly of desmoplakin- and occludin-positive structures during pancreatitis in both wild-type and EPPK^−/− mice (B–E). Scale bars, 20 µm.