<p>Scenarios S1: low macrophage permissiveness; SB: high antiviral and low immuno-modulatory cytokine synthesis; S0: reference; SA: high macrophage permissiveness; S2: low antiviral and high immuno-modulatory cytokine synthesis. AUC (area under the curve) units: macrophages [], other cells [d/ml], cytokines []. Macrophages: infected (), phagocyting (). Adaptive effectors: cellular (), humoral () and regulatory () orientations.</p><p>*Relative AUC are defined within a group of outputs (<i>e.g.</i> the four cytokines , , and ) as the AUC of the outputs expressed as percentages of the sum of the AUC within the group.</p><p>Summary of the virus and immune dynamics for variable host susceptibility and strain virulence.</p
<p>The minimal and maximal values tested were issued from the literature when we found some informat...
The immune mechanisms which determine the infection severity and duration induced by pathogens targe...
<p>Viral loads of the virulent strain (strain 1; blue), and of the less virulent strain (strain 2; r...
<p>Evolution of twelve variables (panels <b>A</b> to <b>L</b>) during the first 30 days of infection...
<p>Scenarios S1 and S2 differ from the reference scenario S0 by their respectively low and high macr...
<p>The state variables represented are: the free viral particles (); the susceptible (), phagocyting...
<p>The immune components selected are the area under the curve (AUC) of <b>A</b>: infected macrophag...
<p>Different trends in Tc or Th cell immune responses were induced by attenuated (A) and virulent (V...
<p>Interactions between macrophages and virus (1) result in macrophage activation by either phagocyt...
International audienceThe immune mechanisms which determine the infection severity and duration indu...
Rows (top-down) indicate the evolutionarily optimal within-host virus growth rate () and the corresp...
Summary of parameters that were distinct between different infection scenarios. Parameters consisten...
<p>Each distinct curve represents simulations from a unique randomly obtained, physiological paramet...
Resistance to infection is often associated with proliferative T-cell responses corresponding to act...
<p>The state variables consist of: the free viral particles (); the susceptible (), phagocyting (), ...
<p>The minimal and maximal values tested were issued from the literature when we found some informat...
The immune mechanisms which determine the infection severity and duration induced by pathogens targe...
<p>Viral loads of the virulent strain (strain 1; blue), and of the less virulent strain (strain 2; r...
<p>Evolution of twelve variables (panels <b>A</b> to <b>L</b>) during the first 30 days of infection...
<p>Scenarios S1 and S2 differ from the reference scenario S0 by their respectively low and high macr...
<p>The state variables represented are: the free viral particles (); the susceptible (), phagocyting...
<p>The immune components selected are the area under the curve (AUC) of <b>A</b>: infected macrophag...
<p>Different trends in Tc or Th cell immune responses were induced by attenuated (A) and virulent (V...
<p>Interactions between macrophages and virus (1) result in macrophage activation by either phagocyt...
International audienceThe immune mechanisms which determine the infection severity and duration indu...
Rows (top-down) indicate the evolutionarily optimal within-host virus growth rate () and the corresp...
Summary of parameters that were distinct between different infection scenarios. Parameters consisten...
<p>Each distinct curve represents simulations from a unique randomly obtained, physiological paramet...
Resistance to infection is often associated with proliferative T-cell responses corresponding to act...
<p>The state variables consist of: the free viral particles (); the susceptible (), phagocyting (), ...
<p>The minimal and maximal values tested were issued from the literature when we found some informat...
The immune mechanisms which determine the infection severity and duration induced by pathogens targe...
<p>Viral loads of the virulent strain (strain 1; blue), and of the less virulent strain (strain 2; r...