ICP22 interacts with pol II and CDK9.

<p>(<b>A</b>) GST-mediated pull-down from HeLa nuclear extract with the recombinant proteins indicated at the top, followed by western blot analysis using anti-pol II and anti-CDK9 antibodies. On the right, a diagram of full-length ICP22 and 193–256 shows the position of the alphaherpesvirus conserved core motif and the GST tags. (<b>B</b>) GST-mediated pull-down of recombinant P-TEFb by the recombinant proteins indicated at the top followed by western blot analysis using an anti-CDK9 antibody.