Model estimates for rates of bacterial replication and killing.

<p>Rapid bacterial replication and killing is observed over the first 6 h following re-challenge; between 6 and 24 h these rates decrease showing that bacteriostatic mechanisms predominate. Maximum likelihood estimates with 95% confidence ellipses for the killing and replication rates of bacteria in the liver (left) and spleen (right) in each experimental group for the periods 0–6 h (solid ellipses) and 6–24 h (dashed ellipses). The rates are expressed as 1og₁₀(CFU) gained or lost per hour (for example, a killing rate of 0.2 means that 37% of bacteria are killed within an hour). Diagonal grid lines indicate net growth rates (replication rate-killing rate).