Effect of PDGF signalling inhibition by Imatinib on gene expression following Prazosin and Extirpation treatment.

<p>mRNA analysis of EDL muscle tissue by RT-PCR from WT and CD248^-/- mice plus no treatment control (-), extirpation (ext) or prazosin (pra) treatment. In addition, all mice were treated with Imatinib throughout the experiment. Gene transcription data were acquired for angiopoietin2 (Ang2: <b>A</b>), endothelial tyrosine kinase (TEK: <b>B</b>), platelet-derived growth factor B (PDGF-B: <b>C</b>), platelet-derived growth factor receptor β (PDGFRβ: <b>D</b>), vascular endothelial growth factor A (VEGF-A: <b>E</b>) and hypoxia-inducible factor 1α (HIF1α: <b>F</b>). Data are shown as relative expression units (2−ΔCt) relative to 18S. Data are mean ± SEM from 6 animals. ANOVA with Bonferroni post-test was performed and no significant differences were observed between any treatments or genotypes.