1<p>Size of the sequence region.</p>2<p>A: two parents and one affected sib; AUU: two parents, one affected and two unaffected sibs, AA: two parents and two affected sibs.</p>3<p>Simulated population.</p><p>Scenarios for type I error and power simulations.</p
<p>A-D, KW, MLM and LM. The “Power” was defined as the detection frequency in 500 repeats for a cert...
Researchers conducting family-based association studies have a wide variety of transmission/disequil...
<p>Significant level is 5%.</p><p>Note: S denotes sample size in trios; L denotes the number of geno...
<p>Measures of power (M1), type I error (M2–M4) and parameter estimate (average OR, empirical standa...
<p>They were termed simulated example 1(A), simulated example 2 (B) and simulated example 3(C) in th...
<p>Powers (left hand plots) are defined as the proportion of replicates (out of 1000) in which both ...
Estimates provided over various confounding simulation scenarios. General simulation parameters: gen...
<p>Type 1 error and power results for the simulation based on a data set with families.</p
a<p>Two tests were conducted to evaluate type I error and power for various sample sizes.</p
<p>Two hundred nuclear families were simulated by admixing 100 from two populations A and B. See <a ...
<p>The left panel of the figure shows the measures of power and type I error rate of rMLM, MLM, S-TD...
<p>The number of children per family varied from 2 to 4, and the number of families varied according...
<p>Significant level is 5%.</p><p>Note: S denotes sample size in trios; L denotes the number of geno...
Disease models for the two pairs of SNPs that contribute to the simulated outcome. Numeric values (e...
<p>Computed sample size, estimated power, and simulated power when <i>δ</i> = 0.50, Type I error <i>...
<p>A-D, KW, MLM and LM. The “Power” was defined as the detection frequency in 500 repeats for a cert...
Researchers conducting family-based association studies have a wide variety of transmission/disequil...
<p>Significant level is 5%.</p><p>Note: S denotes sample size in trios; L denotes the number of geno...
<p>Measures of power (M1), type I error (M2–M4) and parameter estimate (average OR, empirical standa...
<p>They were termed simulated example 1(A), simulated example 2 (B) and simulated example 3(C) in th...
<p>Powers (left hand plots) are defined as the proportion of replicates (out of 1000) in which both ...
Estimates provided over various confounding simulation scenarios. General simulation parameters: gen...
<p>Type 1 error and power results for the simulation based on a data set with families.</p
a<p>Two tests were conducted to evaluate type I error and power for various sample sizes.</p
<p>Two hundred nuclear families were simulated by admixing 100 from two populations A and B. See <a ...
<p>The left panel of the figure shows the measures of power and type I error rate of rMLM, MLM, S-TD...
<p>The number of children per family varied from 2 to 4, and the number of families varied according...
<p>Significant level is 5%.</p><p>Note: S denotes sample size in trios; L denotes the number of geno...
Disease models for the two pairs of SNPs that contribute to the simulated outcome. Numeric values (e...
<p>Computed sample size, estimated power, and simulated power when <i>δ</i> = 0.50, Type I error <i>...
<p>A-D, KW, MLM and LM. The “Power” was defined as the detection frequency in 500 repeats for a cert...
Researchers conducting family-based association studies have a wide variety of transmission/disequil...
<p>Significant level is 5%.</p><p>Note: S denotes sample size in trios; L denotes the number of geno...
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