Royal jelly restored tear secretion in a rat blink-suppressed dry eye model.

<p>A: Changes in body weight. B: Changes in tear secretion (Left). (n = 10 rats) Representative photographs of tear secretion patterns measured by a cotton thread (Right). The arrow shows the wetted length by tear secretion. C: Effect of RJ on corneal surface damage. Changes in the grading score (lower, n = 9 rats), Typical pattern of staining (Upper). Punctate staining appeared in the whole area of cornea surface with the vehicle treatment. D: Histopathological changes in the LG. HE staining (Left upper). VAMP8 immunostaining (Left lower). Scale bar, 20 µm (HE) or 50 µm (VAMP8). Acinar cell size (Right, n = 6 LG). All data represent the mean ± SD. **<i>P</i><0.01, ***<i>P</i><0.001 versus the vehicle.