Time constants of key cellular characteristics during epithelial wound closure.

<p>(<b>A</b>) While the change of cell-covered area per minute of mitomycin c-stimulated cells was significantly diminished as compared to untreated control cells, no significant difference was detected between EGF- and untreated control cells. (<b>B</b>) The temporal dry mass change of mitomycin c-stimulated cells was significantly decreased as compared to EGF-stimulated and untreated control cells. (<b>C,D</b>) No significant differences in the temporal changes of cell layer thickness and cellular volume were detected between EGF or mitomycin c-stimulated cells and untreated control cells. Data are means ±SE; *, <i>P</i><0.05; (the numerical data of the diagrams A–D are summarized in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0107317#pone.0107317.s002" target="_blank">Table S2</a>).