Modular and uniform neuronal networks exhibit different activity patterns during development.

<p><b>A</b>. 10-s raster plots of spontaneous activity of a representative uniform network, recorded by 60 electrodes at four different developmental phases: 16–25 DIV, 26–35 DIV, 36–45 DIV and 46–55 DIV, respectively from top to bottom. Each black dot represents a detected spike. A zoomed network burst is reported above the raster plot at the first developmental time frame (DIV 16–25). <b>B</b>. 10-s raster plots of spontaneous activity of a representative modular network, recorded by 60 electrodes at four different developmental phases: 16–25 DIV, 26–35 DIV, 36–45 DIV and 46–55 DIV, respectively from top to bottom. Each black dot represents a detected spike, and the network confinement is highlighted by the grey shaded area, which corresponds to the top compartment. A zoomed network burst is reported above the raster plot at the first developmental time frame (DIV 16–25).