The anti-tumor effect of CC-I in a subcutaneous mouse tumor model.

<p>(A) Mice were implanted with ten million cells with the SW1088 or CCF-STTG1 cells. The starting tumor size for the CCF-STTG1 cells ranged from 80–100 mm³. The SW1088 cells grew more slowly so CC-I treatment was started when the tumors reached 30 mm³. CC-I was injected intraperitoneally at a concentration of 25 mg/kg body weight once a week for 7 weeks (n = 7∼10). The control group was given PBS in the same volume and regimen (n = 3–8). The tumor slowly reoccurred in the TMZ-sensitive SW1088 astrocytoma injected nude mice but did not reoccur in the TMZ resistant CCF-STTG1 injected nude mice when CC-I was discontinued (beyond 7 weeks). CC-I inhibited the tumor growth and was not lethal in any of the treatment groups. Some error bars are too small to be visible. (B) Mean body weight of mice is presented in grams. Some error bars are too small to be visible.