Validating the estimation of beta.

<p>This figure shows the evolution for of the mean value of across all the clusters. The red dots represent the biological data clustering (i.e the reference in our simulations scheme). The green dots represent the results obtained after clustering simulated data, which shows an underestimation of . To confirm that this underestimation come from the simulation scheme and not the clustering method, we used the simulated data as the reference to generate a "second generation" of simulated data, suppressing the simulation scheme bias (see <a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1003824#pcbi-1003824-g007" target="_blank">Figure 7</a>). The results of this re-simulation are shown by the blue dots, which exhibit no underestimation of . Finally the brown dots represent the mean value of on the same simulated data but spatially randomized, as expected the are now estimated to .