<p>Metaphases were stained with a telomere probe and scored for telomere fusions (TFs). TFs were further classified as “chromosome-type” or “chromatid-type”.</p><p>Analysis of telomere instability in MEFs deficient for DNA-PKcs and/or 53BP1 (<i>Prkdc</i>/<i>Trp53bp1</i> MEFs).</p
Telomeres are the ends of linear eukaryotic chromosomes essential for their stable maintenance. The ...
<p>(<b>A</b>) Two independent lines of 53BP1-deficient cells (MEF #7 and MEF #8) were treated with 4...
Telomeres are specialised structures that protect chromosome ends from degradation and fusion events...
<p>(<b>A</b>) Schematic of types of telomere fusions observed in this study. Left panel: most fusion...
<p>(<b>A</b>) MEFs deficient for ATM and wt controls were treated with NU7026 for 24 hours and the n...
<p>A. Representative normal G-banded karyotype of cultured UCMSC. B. Relative TRAP activity per micr...
<p>(<b>A</b>) Wt MEFs were infected with either of five shRNAs to Lig4 or a control shRNA to GFP and...
Telomeres constitute the ends of the linear eukaryotic chromosomes and are essential for the mainten...
Telomere dysfunction can unleash genome instability or permanently arrest cell proliferation, and th...
The DNA-dependent protein kinase catalytic subunit (DNA-PKcs) is critical for DNA repair via the non...
Linear genomes end in characteristic structures consisting of repetitive DNA and proteins: the telom...
Telomeres are specialised structures that that cap the ends of chromosomes; and prevent the natural ...
Telomeres are composed of repetitive G-rich sequence and an abundance of associated proteins that to...
Telomeres are the repetitive DNA sequence and associated proteins found at the ends of linear chromo...
AbstractWe report cytologic and genetic data indicating that telomere dysfunction induces a DNA dama...
Telomeres are the ends of linear eukaryotic chromosomes essential for their stable maintenance. The ...
<p>(<b>A</b>) Two independent lines of 53BP1-deficient cells (MEF #7 and MEF #8) were treated with 4...
Telomeres are specialised structures that protect chromosome ends from degradation and fusion events...
<p>(<b>A</b>) Schematic of types of telomere fusions observed in this study. Left panel: most fusion...
<p>(<b>A</b>) MEFs deficient for ATM and wt controls were treated with NU7026 for 24 hours and the n...
<p>A. Representative normal G-banded karyotype of cultured UCMSC. B. Relative TRAP activity per micr...
<p>(<b>A</b>) Wt MEFs were infected with either of five shRNAs to Lig4 or a control shRNA to GFP and...
Telomeres constitute the ends of the linear eukaryotic chromosomes and are essential for the mainten...
Telomere dysfunction can unleash genome instability or permanently arrest cell proliferation, and th...
The DNA-dependent protein kinase catalytic subunit (DNA-PKcs) is critical for DNA repair via the non...
Linear genomes end in characteristic structures consisting of repetitive DNA and proteins: the telom...
Telomeres are specialised structures that that cap the ends of chromosomes; and prevent the natural ...
Telomeres are composed of repetitive G-rich sequence and an abundance of associated proteins that to...
Telomeres are the repetitive DNA sequence and associated proteins found at the ends of linear chromo...
AbstractWe report cytologic and genetic data indicating that telomere dysfunction induces a DNA dama...
Telomeres are the ends of linear eukaryotic chromosomes essential for their stable maintenance. The ...
<p>(<b>A</b>) Two independent lines of 53BP1-deficient cells (MEF #7 and MEF #8) were treated with 4...
Telomeres are specialised structures that protect chromosome ends from degradation and fusion events...