The biological activity of the recombinant HCV core protein.

<p>Before each test, the monocytes (THP-1) differentiate to macrophages (mTHP-1) after incubation with PMA (40 ng/ml) for 48 h. Real-time PCR analysis of C1qR and TLR4 that expressed by mTHP-1 cells treated with PBS (control) or LPS (1 µg/ml) or HCV core (10 µg/ml). (A) The mRNA level of C1qR. #<i>p</i><0.05 indicates alpha value as compared to control and LPS groups; (B) The mRNA level of TLR4. *<i>p</i><0.05 indicates alpha value as compared to control and HCV core protein groups.