Inhibition of the production of 4-HNE in hair cells.

<p>Utricles were cultured for 12 h without neomycin (a, b), with neomycin (c, d), or with both neomycin and coenzyme Q10 (e, f). The hair cell layer was identified using Texas Red-conjugated phalloidin (red). 4-HNE was labeled using a specific antibody (green). Signals of 4-HNE were seen in utricle hair cells 12 h after exposure to neomycin. These 4-HNE signals were strongly inhibited by coenzyme Q10 treatment.