Effect of nicotine on Ang II-induced contractions and Ca²⁺ mobilization in mesenteric arteries in adult offspring.

<p>Ang II-induced contractions of pressurized mesenteric arteries were determined in male adult offspring that had been exposed in utero to saline control or nicotine. <b>A</b>, Typical recordings of Ang II (100 nM)-induced decreases in the arterial diameter and increments in [Ca²⁺]_i in the same tissue from saline control and nicotine-treated groups. Ang II-induced contractions (<b>B</b>), [Ca²⁺]_i (<b>C</b>), and arterial diameter change/[Ca²⁺]_i ratio (<b>D</b>) in mesenteric arteries from the control and nicotine-treated animals. Data are means ± SEM of tissues from saline control (n = 7) and nicotine (n = 8). The sample sizes represent the animal number from different litters of each group. Data were analyzed by student <i>t</i>-test. ^*P <0.05 vs. control.