Histopathology in susceptible A/J and resistant C3H/HeOuJ <i>P</i>. <i>aeruginosa</i>-infected mice.

<p>The lungs of A/J (<b>A–D</b>) and C3H/HeOuJ (<b>E–H</b>) were stained with H&E (<b>A–C, E–H</b>) and in immunofluorescence with specific antibody against <i>P. aeruginosa</i> (red) (<b>D, H</b>). Counterstaining was performed with 49,6-Diamidino-2-phenylindole dihydrochloride (DAPI) (blue). After time course analysis, extensive infection and inflammation were visible in murine lungs with major differences between A/J and C3H/HeOuJ. Arrows indicate aggregates of lynphocytes infiltrates. Bars, 200 µm for H&E images, 100 µm for immunofluorescence images. Severity of lesions and lung involvement was scored as reported in <b>Fig S4</b>.