Perfusion parameters and maps.

<p>(<b>A</b>) Elevated extravascular extracellular volume fraction v_e, in NK+mAb9.2.27 compared to monotherapy animals from cohort 1 (received 1 million NK cells), *p<0.05, **p<0.001 ***p<0.0001. (<b>A left panels</b>) Parametric maps visualising intratumoral heterogeneity in v_e in representative control, monotherapy and NK+mAb9.2.27 treated animals at 7 days. Intensity scale shows minimum (blue voxels) and maximum (red voxels) intensity levels. (<b>B</b>) Increased interstitial extracellular volume fraction, v_e, elevated in NK+mAb9.2.27 compared to NK cells and mAb9.2.27 monotherapy animals, and decreased v_e in NK cell monotherapy compared to untreated control from cohort 2 (treated with 2 million NK cells), *p<0.05, **p<0.001, ***p<0.0001. (<b>B, left panels</b>) Parametric maps visualising intratumoural heterogeneity in v_e in control, monotherapy and NK+mAb9.2.27 treated animals at 17 days. (<b>C</b>) Significant association between ADC and v_e in the NK+mAb9.2.27 (R² = 0.798, p = 0.041) and NK cell monotherapy animals (R² = 0.993, p = 0.004). Graphs in A and B represent estimated marginal mean±95% confidence intervals.