Exercise does not reverse cisplatin induced inflammation and glucose intolerance.

<p>After 6 weeks of cisplatin treatment, A) change in fat mass (FM) by DXA scanning, and B) blood glucose levels during a glucose tolerance test, were determined. Before euthanasia, half of the mice performed a single bout of acute exercise (60 min swimming). Gene expression of C) TNF-α, D) IL-6 and E) IL-10 and F) serum IL-6 in mice euthanized before swimming (REST) or immediately after the swimming exercise (SWIM). ND: Values below detection rate. Results are presented as means ± SEM (n = 8). Statistical analysis was performed by 2-way ANOVA with Bonferroni's post hoc test and post hoc T-test for the CIS group. ¤ indicates cisplatin treatment effect (P<0.05) by 2-way ANOVA. *P<0.05, **P<0.01, ***P<0.001, ****P<0.0001 indicates significance in post hoc tests indicates compared to non-exercising control or as indicated by the lines.