The effect of home cage running wheels on disease course in SOD1^G93A mice.

<p>Graphs showing rotarod (A), survival (B), onset determined by a 20% reduction in rotarod performance (C), and onset determined by a 20% decrease in running wheel activity (D) in littermate SOD1^G93A mice either with or without access to a home cage running wheel. In A–C mice with access to running wheels are shown in purple. In D onset determined by a 20% decline in the distance run is shown in red, time spent running is shown in blue and average speed is shown in black.