The effect of controlling pH on the resolution.

<p>(a) Effects of pH regulation on the conversion ratio. (b) Effects of pH regulation on <i>ee</i>_D. The substrate (100 mL, 1 L) was added to the reactor with a flow rate of 12 mL min⁻¹. When the resolution was performed for 16 h, the pH was adjusted from 8.5 to approximately 5 to precipitate the <i>trans</i>-cinnamic acid from the reaction solution. The <i>trans</i>-cinnamic acid was removed by filtration, and then the pH of the reaction was readjusted to 8.5, and the resolution was continued.