BLT mouse peripheral blood harbors few unswitched and switched memory B cells relative to adult human peripheral blood.

<p>(<b>A–B</b>) Representative flow cytometry analyses for CD27 and IgD expression on B cells in adult human PB and BLT mouse PB shows a paucity of unswitched/switched memory B cells in BLT mouse blood. (adult PB, n = 5; BLT PB, n = 18). (<b>C–D</b>) Flow cytometry plots and bar graph for CD38 and IgD expression on CD19⁺ cells reveal an absence of switched memory B cell populations in BLT mouse PB while these populations are present in adult human PB (adult PB, n = 5; BLT PB n = 16). * indicates a p value less than 0.05. ** indicates a p value less than 0.01. *** indicates a p value less than 0.001. Comprehensive statistical analyses are presented in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0108663#pone-0108663-t001" target="_blank">Table 1</a>.