Genetic background of mice used at different stages of the study.

<p>(<b>A</b>) Adult mice from (<i>Le-Cre^Tg/−</i>; <i>Pax6^+/+</i> × <i>Le-Cre^−/−</i>; <i>Pax6^fl/+</i>) crosses in stage 1. (<b>B</b>) Adult mice from (<i>Le-Cre^Tg/−</i>; <i>Pax6^+/+</i> × <i>Le-Cre^−/−</i>; <i>Pax6^fl/+</i>) crosses used for wound healing experiment in stage 2. (<b>C</b>) Fetal and juvenile mice from (<i>Le-Cre^Tg/−</i>; <i>Pax6^+/+</i> × <i>Le-Cre^−/−</i>; <i>Pax6^fl/+</i>) crosses in stage 3. (<b>D</b>) Adult mice from (<i>Le-Cre^Tg/−</i>; <i>Pax6^+/+</i> × <i>Le-Cre^−/−</i>; <i>Pax6^fl/+</i>) crosses in stage 3. (<b>E</b>) Adult reporter mice from (<i>Le-Cre^Tg/−</i> × <i>Z/AP</i>) crosses in stage 3. (<b>F</b>) Adult mice from (<i>Le-Cre^Tg/−</i>; <i>Pax6^+/+</i> × <i>Le-Cre^−/−</i>; <i>Pax6^fl/+</i>) crosses in stage 4. (<b>G</b>) Adult mice from (<i>Le-Cre^Tg/−</i>; <i>Pax6^fl/+</i> × <i>PAX77^Tg/−</i>) crosses. See <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0109193#pone.0109193.s004" target="_blank">Table S1</a> and <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0109193#s2" target="_blank">Materials and Methods</a> for further details.