Interaction profiles of CT are altered across the cell cycle and cell types.

<p>Since each CT has two homologs there are four possible interactions in each nucleus. (<b>A–D</b>) Differences across the cell cycle- The percent of cells with only 1 interaction (<b>A</b>) and the percent of cells that have 2 or more interactions (<b>B</b>) in WI38 are shown for each of the 21 pairwise combinations of CT (G1, n = 46; S, n = 47). The percentage with only 1 (<b>C</b>) and 2 or more (<b>D</b>) in 10A are shown (G1, n = 56; S, n = 54); blue bars are G1 and red are S. (<b>E–H</b>) differences between cell types- The percent of cells with only 1 interaction (<b>E</b>) and the percent of cells that have 2 or more interactions (<b>F</b>) in G1 of WI38 and 10A are shown. The percent with only 1 (<b>G</b>) and 2 or more (<b>H</b>) in S of WI38 and 10A are shown, green bars are WI38 and black are 10A. error bars = SEM. Black asterisks indicate chi-square test, p<0.05, while red indicate p<0.10. Full p values are presented in <a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1003857#pcbi.1003857.s012" target="_blank">Tables S3</a>,<a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1003857#pcbi.1003857.s015" target="_blank">S6</a>.