Treatment with HBOT or PFD decreased ear swelling in the AD lesions.

<p>Gross examination of the AD lesions at the end of the experiment (day 38) shows skin thickening, crust-formation and scaling, which was apparently attenuated by treatment with HBOT, PFD or steroid (A). Measurement of the ear thickness showed significant swelling in the AD lesions from day 16 (B). Ear swelling was significantly attenuated in the mice treated with HBOT, PFD or steroid from day 30. Data are expressed as the mean ± SD (<i>n</i> = 12). *<i>P</i><0.05, compared between the control and other groups; ^¶<i>P</i><0.05, compared between AD-NT and AD – HBO, AD – PFD or AD – Steroid groups.