ABR threshold shifts.

<p>Inhibition of the JAK2/STAT3 pathway improves auditory brainstem response (ABR) threshold recovery from exposure to 4–48 kHz loud sound at 110 dB SPL for 3 hours. Mice were treated with JSI-124 (Cucurbitacin I) (1 mg/kg) or DMSO (Control) at 48 hours, 24 hours and 1 hour prior to sound exposure (n = 6 mice/group). ABR measurements were performed before (Baseline: normal hearing threshold), at 1 hour post (TTS: temporary threshold shift) and at 2 weeks post (PTS: permanent threshold shift) noise exposure. Significant protection was observed at 16 and 24 kHz. Data are presented as mean±SEM. *<i>P</i><0.05.