Triptolide treatment rescues spatial learning and memory deficits in APP/PS1 mice.

<p><b><i>A</i></b>, Escape latency during the acquisition phase of the Morris water maze test. Untreated control APP/PS1 mice exhibited learning deficits in locating the submerged escape platform, whereas triptolide-treated mice performed similarly to non-Tg mice. <b><i>B</i></b>, The number of crossings over the previously hidden platform area in the probe trial. Triptolide-treated group crossed the platform area significantly more often than control APP/PS1 group. <b><i>C</i></b> and <b><i>D</i></b>, Escape latency and swimming speed during the visible platform phase of the Morris water maze test. No significant differences were observed among different groups. For clarity, error bars are shown in only one direction. N = 7 mice/group; Age = 8 months; *, <i>P</i><0.05.