Overexpression of PD-1H on monocytes in HIV infection.

<p>A representative histogram (a) and cumulative data (b) of PD-1H expression on CD14 gated PBMC from normal and HIV-infected donors. MFI, mean fluorescence intensity. EC, elite controllers. C, controllers. * indicates p<0.05, Kruskal Wallis test followed by Dunn multiple comparison tests. c) PD-1H expression on CD14+ (classic) and CD16⁺ (activated) monocytes from HIV⁺ donors. Each horizontal line represents expression on CD14+ and CD16+ monocytes from the same individual. d) The mRNA expression level for indicated cytokines in <i>ex vivo</i>-isolated monocytes from normal and HIV-infected individuals was assessed by real time PCR. Mean + SD from PBMCs from five donors. (PD-1H^HI MFI: 1600-4500; PD-1H^LO MFI 700-1500). * = p<0.05 (One way ANOVA followed by Tukey test).