Airway responsiveness as measured by resistance to intranasal methacholine.

<p>Airway resistance curves to methacholine for (A) WT and (B) PHIL mice; (C) Maximal airway resistance in response to 25 mg/mL methacholine <i>i.n.</i> (n = 10 per group). Data are presented as the maximal resistance between 3.1–25 mg/mL minus the baseline value (0 mg/ml) for each mouse. In WT and PHIL mice, there was a significant increase in methacholine airway responsiveness in HDM versus SAL in WT and PHIL mice. This was significantly attenuated by treatment with AMD3100. Data are expressed as mean ± SEM. *p<0.05 compared with SAL; #p<0.05 compared with HDM.