Flavokawain A inhibits the proliferation and induces apoptosis in both MCF-7 and MDA-MB231.

<p>A) The percentage of cell viability of MDA-MB231, MCF-7 and MCF-10A when treated with Flavokawain A for 72 hours.B) The percentage of BrdU incorporation in MCF-7 and MDA-MB231 after being treated with three different concentrations of flavokawain A for 48 hours.C) Histogram analysis of the cell cycle machinery in MCF-7 and MDA-MB231 after being treated with three different doses of flavokawain A for 12 and 24 hours.D) Histogram analysis of Annexin V/FITC in MDA-MB231 and MCF-7 after being treated with three different concentrations of flavokawain A after 48 hours. Data are expressed as mean ± S.E.M with p value< 0.05.