Sertraline inhibits depression-like behavior and plasma Hcy content in CUMS rats.

<p>Sucrose preference, open field test scores, 5-HT level in the hippocampus and total plasma Hcy were measured as described in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0106625#pone-0106625-g001" target="_blank">Figure 1</a>. <b>A.</b> Sertraline inhibited the decline of sucrose preference induced by CUMS. <b>B.</b> Sertraline inhibited the decline of the open field test score induced by CUMS. <b>C.</b> Sertraline decreased the immobility time of the forced swimming test induced by CUMS. <b>D.</b> Sertraline inhibited the decline in the 5-HT level in hippocampus induced by CUMS. <b>E.</b> Sertraline inhibited the increase in the plasma Hcy level induced by CUMS. Values represent the group mean ± structural equation modeling (SEM) (n = 8 rats per group). *<i>P</i><0.05, repeated measures ANOVA followed by Tukey's multiple comparison tests.