HPSE induces gene expression of pro-inflammatory cytokines from human peripheral blood mononuclear cells.

<p>Expression of IL-8, TNF, IL-1β, IL-6, IL-10 and IL-12p35 mRNA by RT-PCR in PBMCs incubated in the presence or absence of 10 µg/ml HPSE for 4, 12 or 24 h. Data are expressed as the mean level of expression normalised to <i>ubc e2d2</i>, data represent the mean ±SEM of triplicate samples, results are representative of three independent experiments. *p = <0.05, **p = <0.001 unpaired, two-tailed Student's t-test.