SERPINA3K (SA3K) downregulated Wnt signaling pathway.

<p>(<b>A</b>) Representative images of Western blot with anti-β-catenin and anti-LRP6 antibodies in the PECs after treatment of SA3K at concentration of 0, 80, 160, and 320 nM for 24 hours. (<b>B</b>) Statistic analysis of the western blot data of β-catenin. Data were presented as mean±SEM; n = 4; **: p<0.01. (<b>C</b>) Statistic analysis of the Western blot data of LRP6. Data were presented as mean±SEM; n = 5; *: p<0.05. (<b>D</b>) Representative images of Western blot with anti-nonphospho-β-catenin antibody in the PECs after treatment of SA3K at concentration of 0, 80, 160 and 320 nM for 24 hours. (<b>E</b>) Statistic analysis of the Western blot data of nonphospho-β-catenin. Data were presented as mean±SEM; n = 3; *: p<0.05, **: p<0.01.