ZFP36L1 is induced in macrophages in response to infectious and inflammatory stimuli.

<p>(A) Graphic representation of Zfp36 proteins showing TIS11B like domain and two tandem zinc fingers, which facilitate binding to RNA. Immunoblot analysis of protein derived from (B) Alveolar macrophage derived cells (MH-S cell line) stimulated <i>in vitro</i> with <i>E. coli</i>, <i>S. pneumoniae</i> serotype 3 or 19, LPS, or a combination TNF- α and IL-1β. (C) MH-S cells during a time course of <i>E. coli</i> infection (D) Primary murine alveolar macrophages stimulated <i>in vitro</i> with <i>E. coli</i> or (E) Primary human alveolar macrophages stimulated <i>in vitro</i> with <i>E. coli</i>. Immunoblot results are representative of three independent experiments.