ZFP36L1 deficient macrophages are capable of maximal cytokine expression.

<p>qRT-PCR analysis of primary alveolar macrophages collected from Cre (−) or Cre (+) mice, and stimulated with (A,F) vehicle or <i>E. coli</i> for 6 hours (n = 3) or (B,D) LPS (n = 7,5). Results indicate fold change relative to unstimulated Cre (−) (for A,F) or Cre (−) (B,D) (E) Relative TNF- α and (F) IL-6 half lives in Cre(−) or Cre (+) alveolar macrophages after 2 hours of LPS stimulation followed by transcriptional blockade by Actinomycin D.