<p>(A) Two OPN-shRNA plasmids (shOPN1 and shOPN2) and one empty vector (ev) plasmid were transiently transfected (24 h) in MG63 cells. OPN protein expression was downregulated by both shOPN1 and shOPN2. After treatment with the chemical hypoxia agent CoCl<sub>2</sub> (100 µM, 6 h), GLUT1 (B) and GLUT3 (C) mRNA expression was markedly upregulated in the empty vector (ev) group. This effect was significantly antagonized by OPN knockdown (shOPN1 and shOPN2) in MG63 cells. Data are presented as the mean ± S.E.M. (n = 4), *p≤0.05, compared with the empty vector group (ev) in the control group, #p≤0.05, compared with the empty vector group (ev) in the CoCl<sub>2</sub> treatment group.</p
<p>2-NBDG, a fluorescent d-glucose analog, was used as an indicator of glucose uptake. Note that tre...
Background. Osteopontin (OPN) is a phosphorylated glycoprotein. There is increasing evidence that th...
Osteopontin (OPN) is a secreted protein present in bodily fluids and tissues. It is subject to multi...
<p>OPN (10 ng/ml) increased GLUT1 and GLUT3 protein expression in MG63 cells. This effect was signif...
<p>MG63 osteosarcoma cells were treated with the chemical hypoxic agent CoCl<sub>2</sub> (100 µM). O...
<p>OPN (24 h) increased GLUT1 (A) and GLUT3 (B) protein levels in a concentration-dependent manner i...
<p>(A) The mRNA levels of glucose transporter (GLUT) 1, 2, 3, 4, 6, 8, 10, and 12 were evaluated usi...
Osteosarcoma is the most common primary malignancy of bone. Even after the traditional standard surg...
Osteosarcoma is the most common primary malignancy of bone. Even after the traditional standard surg...
Osteosarcoma is the most common primary malignancy of bone. Even after the traditional standard surg...
Background: Tumor hypoxia is a known risk factor for reduced response to radiotherapy. The evaluatio...
Background Tumor hypoxia is a known risk factor for reduced response to radiotherapy. The evaluatio...
Pancreatic stellate cells (PSCs), a key component of the tumor microenvironment, contribute to tumor...
<p>A) Oxidoreductase genes commonly induced by osteopontin-c and hydrogen peroxide in soft agar. Mic...
Abstract: Osteopontin (OPN), a secreted acidic phosphoglycoprotem found in many tissues and body flu...
<p>2-NBDG, a fluorescent d-glucose analog, was used as an indicator of glucose uptake. Note that tre...
Background. Osteopontin (OPN) is a phosphorylated glycoprotein. There is increasing evidence that th...
Osteopontin (OPN) is a secreted protein present in bodily fluids and tissues. It is subject to multi...
<p>OPN (10 ng/ml) increased GLUT1 and GLUT3 protein expression in MG63 cells. This effect was signif...
<p>MG63 osteosarcoma cells were treated with the chemical hypoxic agent CoCl<sub>2</sub> (100 µM). O...
<p>OPN (24 h) increased GLUT1 (A) and GLUT3 (B) protein levels in a concentration-dependent manner i...
<p>(A) The mRNA levels of glucose transporter (GLUT) 1, 2, 3, 4, 6, 8, 10, and 12 were evaluated usi...
Osteosarcoma is the most common primary malignancy of bone. Even after the traditional standard surg...
Osteosarcoma is the most common primary malignancy of bone. Even after the traditional standard surg...
Osteosarcoma is the most common primary malignancy of bone. Even after the traditional standard surg...
Background: Tumor hypoxia is a known risk factor for reduced response to radiotherapy. The evaluatio...
Background Tumor hypoxia is a known risk factor for reduced response to radiotherapy. The evaluatio...
Pancreatic stellate cells (PSCs), a key component of the tumor microenvironment, contribute to tumor...
<p>A) Oxidoreductase genes commonly induced by osteopontin-c and hydrogen peroxide in soft agar. Mic...
Abstract: Osteopontin (OPN), a secreted acidic phosphoglycoprotem found in many tissues and body flu...
<p>2-NBDG, a fluorescent d-glucose analog, was used as an indicator of glucose uptake. Note that tre...
Background. Osteopontin (OPN) is a phosphorylated glycoprotein. There is increasing evidence that th...
Osteopontin (OPN) is a secreted protein present in bodily fluids and tissues. It is subject to multi...