The mutant status of the <i>NOTCH2</i>.

<p>(A) The extracellular domain of Notch2 contains epidermal growth factor (EGF)-like repeats, three cysteine-rich LIN/Notch repeats (LNR) and heterodimerization domain (HD). The cytoplasmic domain contains RBP-Jκ associated molecule (RAM) domain, six ankyrin/CDC10 repeats (ANK) including two nuclear localization signals (NLS), Notch cytokine response (NCR) domain, transactivation domain (TAD) and PEST (proline-, glutamic acid-, serine- and threonine-rich) domain. There is a transmembrane domain (TM) between extracellular domain and cytoplasmic domain. The identical mutation of the three DLBCLs located at 2436^th amino acid in the PEST domain, which converted a tryptophan (TGG) into a termination codon (TGA), and resulted in a truncate Notch2. (B) The identical mutation of the three DLBCLs was at the nucleotide 7605 (G/A) in the human <i>NOTCH2</i> cDNA sequence. In the matched surrounding non-tumor tissues of both No. 505 and No. 646, the 7605 site showed “G” which was identical to the germline sequences; but matched non-tumor tissue was not available in No. 445.