Expression of immune molecular module genes in melanomas predicts patient survival.

<p>We compared top-scoring immune molecular modules from the three effective groups for their ability to predict survival of melanoma patients. Shown are KM plots and p-values for the indicated modules. Magenta curves, patients having higher than median expression of module genes; teal curves, patients having lower than median expression of module genes. A) IRF7.mod; B) MAF.mod; and C) KLRD1.mod. D) Dose-dependent effect of ISG levels at predicting patient survival. Melanoma patients were stratified into three groups (ISG hi, ISG med and ISG lo) according to their expression of IRF7 marker modules genes (<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0109760#pone.0109760.s007" target="_blank">Table S3</a>). E) LCK protein expression data supports higher levels of T cell immune filtrate in ISG hi samples. RPPA measurements for LCK from TCGA were compared for samples in ISG hi and ISG lo groups (N = 90 and N = 84 samples, respectively.